New publication provides in-depth assessment of analytical methods to authenticate ginkgo leaf extracts
AUSTIN, Texas, May 10, 2022 (GLOBE NEWSWIRE) -- The ABC-AHP-NCNPR Botanical Adulterants Prevention Program (BAPP) announces the publication of a new Laboratory Guidance Document (LGD) on ginkgo (Ginkgo biloba) leaf extracts. Ginkgo leaf extracts are widely used around the globe to improve mental performance, for circulatory issues such as peripheral arterial occlusive disease, and for vertigo and tinnitus. In the United States, ginkgo leaf extract dietary supplements have been consistently among the 25 top-selling herbal supplements with over $33 million in sales in 2020 in the natural and mass-market channels combined.1 Over the past 20 years, at least 27 publications in the peer-reviewed scientific literature have documented cases of adulteration of ginkgo leaf extract ingredients and finished consumer products. Such adulteration generally involves the addition of undeclared flavonol-rich ingredients or highly purified flavonoids (e.g., quercetin or rutin) from lower-cost sources, most commonly extracts or purified fractions of the flowers and leaves of Japanese sophora (Styphnolobium japonicum, syn. Sophora japonica). Of the 501 samples analyzed in these 27 papers, 242 (48%) were considered to be adulterated according to criteria established by the authors of each of these publications, suggesting that ginkgo leaf extract adulteration is widespread. Undeclared added materials typically are rich in rutin and/or quercetin in order to increase the extract content of flavonol glycosides to 24%, the minimum amount specified on the labels of most commercial dietary supplements to meet the same standardization requirement as the extract EGb761® (Dr. Willmar Schwabe GmbH & Co. KG, Karlsruhe, Germany) — the pioneering and most clinically tested ginkgo leaf extract in the world. Since both rutin and quercetin are also found in ginkgo leaves, the detection of adulteration of commercial ginkgo materials can be challenging. The new LGD assesses the usefulness of 78 laboratory analytical methods to authenticate ginkgo leaf extract and/or detect ginkgo leaf extract adulteration. The document was compiled and written by Stefan Gafner, PhD, chief science officer of the American Botanical Council (ABC) and technical director of BAPP. It was peer reviewed by 30 experts from academia, government, and the herbal dietary supplement industry in the United States and internationally. Gafner explained: “Finding a suitable analytical method to authenticate ginkgo leaf extracts is time-consuming at least in part because of the large number of methods available in the peer-reviewed literature, national pharmacopeias, and other official compendia. Not many botanical ingredients have been subject to such a vast body of analytical work dedicated to its quality control. We hope that this is where the ginkgo laboratory guidance document can be of value to the international medicinal plant community since it provides an overview of relevant, reliable, and fit-for-purpose methods in a single document.” “Standardized ginkgo leaf extract is one of the most clinically researched phytomedicinal products in the world,” said Mark Blumenthal, founder and executive director of ABC and founder and director of BAPP. “Many consumers purchase ginkgo products and are sometimes recommended to use them by their health care practitioner in the hope that these products will deliver a clinically documented health benefit. However, if the product contains an intentionally adulterated extract, it is not likely that it will produce the health benefits observed in published clinical trials. Adulteration of ginkgo, or of any herb product, is a great disservice to the millions of people who wish to improve or maintain their health naturally.” The ginkgo leaf extract LGD is the 13th publication in the series of LGDs and the 73rd peer-reviewed publication published by BAPP. As with all BAPP publications, LGDs are freely accessible on the Program’s website (registration required). About the ABC-AHP-NCNPR Botanical Adulterants Prevention Program The ABC-AHP (American Herbal Pharmacopoeia)-NCNPR (National Center for Natural Products Research at the University of Mississippi) Botanical Adulterants Prevention Program is an international consortium of nonprofit professional organizations, analytical laboratories, research centers, industry trade associations, industry members, and other parties with interest in herbs and medicinal plants. The program advises industry, researchers, health professionals, government agencies, the media, and the public about various challenges related to adulterated botanical ingredients sold in commerce. To date, more than 200 US and international parties have financially supported or otherwise endorsed the program. To date BAPP has published 73 extensively peer-reviewed articles, including Botanical Adulterants Prevention Bulletins, Laboratory Guidance Documents, and “Botanical Adulterants Monitor” e-newsletters. Reference
1. Smith T, Majid F, Eckl V, Morton Reynolds C. Herbal supplements sales in US increase by record-breaking 17.3% in 2020. HerbalGram. 2021(131):52-65. Available at: www.herbalgram.org/resources/herbalgram/issues/131/table-of-contents/hg131-mkrpt/. Accessed April 18, 2022. About the American Botanical Council
Let's look at two stocks that boast significant upside potential, going by average price targets set by analysts on the street: Moderna (NASDAQ: MRNA) and CRISPR Therapeutics (NASDAQ: CRSP). Biotech giant Moderna fell along with the broader market in recent months. Moderna currently generates revenue from just one product: its coronavirus vaccine.
Despite the popularity of vegan and vegetarian diets, a majority of people in the U.S. still do eat meat. In fact, according to a 2021 survey from Ipsos, 9 in 10 Americans currently include meat as part of their diet. With that in mind, it won't be hard for most to spot the symptoms of a concerning health condition that's becoming more and more of a problem thanks to another rising trend. Researchers are warning that the increasing prevalence of one pest across the country could have serious con
Hundreds of health care workers gathered outside a Nashville courthouse on Friday to protest the sentencing of a former Tennessee nurse facing up to eight years in prison for mistakenly causing the death of a patient
Crispr Therapeutics said Thursday it will unveil the first data from human studies of its gene-edited lymphoma drug — and CRSP stock popped.
Less well known pain-inducing conditions include trigeminal neuralgia- often described as an electric shock shooting through the face
The pill has become an increasingly important tool in the nation’s defense against COVID-19 as mask mandates have lifted and people have returned to their non-distanced lives.
Jean Hynes, manager of the Vanguard Health Care fund, is focused on big themes in healthcare—and stocks like Anthem and Eli Lilly.
Stanislaus County’s daily case rate for COVID-19 infections was 8.26 per 100,000 population Tuesday, more than double the rate a month ago.
It’s expected that, after two years of multiple disruptions caused by the COVID-19 pandemic, there would be repercussions on our collective mental health. As recent research has shown, it is heavily impacting children and teens.
Biogen and development partner Eisai are looking to get their next Alzheimer's drug to market using the FDA's accelerated approval pathway.
"It's creepy and gross. Stop that."View Entire Post ›
Earlier in April, the Marijuana Opportunity Reinvestment and Expungement Act (MORE) was narrowly passed by the United States House of Representatives by a vote of 220-204. Marijuana use was legal until 29 U.S. states banned it between 1916 and 1931.
The Duke of Cambridge has personally delivered a damehood to the home of Deborah James, visiting with her family to honour her campaign to raise awareness of bowel cancer.
Christie Brinkley, 68, says “It’s not about the size of your thighs,” while posing with coral to talk body positivity, health, and weight loss advice.
Top leaders of the U.S. Conference of Catholic Bishops called on the faithful to pray and fast Friday, in hopes the Supreme Court is on track to overturn the constitutional right to abortion. A recently leaked Supreme Court draft opinion suggests that a majority of the nine justices are poised to reverse the 1973 Roe v. Wade decision – a move that would allow individual states to outlaw abortion.
Trulieve Cannabis Corp reported a 64% jump in first-quarter revenue on Thursday that beat estimates, on the back of wider acceptance and demand for pot and related products. More states in the U.S are moving towards allowing sale of recreational cannabis, with 18 already on board, underscoring continued support and demand for cannabis since the imposition of lockdowns during the COVID-19 pandemic. The results come a month after the U.S. House of Representatives passed a bill to end the federal ban on marijuana, though the measure was seen as unlikely to pass the Senate.
More than 10% of the 1,234 adult patients were in intensive care units as a disease subvariant drives new infections across the state.
Nurses from across Florida will be in Tallahassee to demand more staffing, better pay and better work conditions.
Medtronic plc (NYSE: MDT), a global leader in healthcare technology, today announced that it has completed the acquisition of Intersect ENT, expanding the company's comprehensive ear, nose, and throat (ENT) portfolio with innovative products used in sinus procedures to improve post-operative outcomes and to treat nasal polyps.
The party isn't done voting on abortion rights this year. But its members admit, with striking candor, that they can't pass anything without bigger majorities.