It is a perennial creeping herbaceous plant.It grows mainly at the edge of the forest, the leaves are alternate phyllotaxis, and there are multicellular white hairs on both sides, but they disappear soon.It is narrow egg-shaped oval or narrow egg-shaped, and the apex leaflet is 4-8cm long and 2-3cm wide with a small petiole, has a sharp tip, has fine hairs on the surface veins, and has serrations on the edge.Flowers bloom in August-September, yellow-green, in cone-shaped inflorescences or raceme-conical inflorescences, 8-15cm long.The calyx lobe is very small and the corolla is divided into 5 pieces. The lobe is about 3mm long, lanceolate, and the tip is long and pointed.Fruits are berries, 6-8mm in diameter, round, black-green, mature, with one horizontal line in the upper half, and seeds are about 4mm long.The nodes of the stem have white hairs, and they grow tangled here and there, but they also climb with tendrils.National Arboretum, National Species Knowledge Information System (http://www.nature.go.kr)National Institute of Biological Resources, Biodiversity of the Korean Peninsula (https://species.nibr.go.kr)Jeju Special Self-Governing Province, Halla Arboretum (http://sumokwon.jeju.go.kr)[Korean Paper] Anti-inflammatory Effect of the Extract of Gynostemma pentaphyllum cell from Ullengdo Island as Korean Endemic Plant[Korean Paper] Effects of Gynostemma pentaphyllum Callus Extract on Anti-inflammation, Anti-allergy, and Alleviation of Keratinocyte Damage Caused by S. aureus[Korea Paper] Physiological activity of the extract from Dolwoe (Gynostemma pentaphyllum Makino) leaves tea by different ethanol concentrations according to ethanol concentration[Korean Paper] Antioxidative and Cellular Protective Effects of Dolwoe (Gynostemma pentaphyllum Makino) Extracts against Oxidative Stress[Korean Paper] Gypenosides, the cancer buster from Gynostemma pentaphyllum (Thunb.) Makino and the apoptotic pathways: a reviewOriental pharmacy and experimental medicine 163, pp.153 - 164 (2016)[Korea Paper] Identification of Collagen Synthesis Activation from the Extracts of Gynostemma pentaphyllum Leaves[Korean Paper] Ameliorating Effects of Herbal Ethanol Extract from Gynostemma pentaphyllum on Chronic Stress-Induced Anxiety in Mice[International Paper] Mechanism of gypenosides of Gynostemma pentaphyllum inducing apoptosis of renal cell carcinoma by PI3K/AKT/mTOR pathwayHui Liu, Xiuming Li, Yu Duan, Jin-Bo Xie, Xiang-Lan PiaoJournal of ethnopharmacology 271, pp.113907 (2021)[Overseas Papers] Saponin extracts from Gynostemma pentaphyllum (Thunb.) Makino display sedative-hypnotic and anxiolytic effectsChun-Yan Shen, Pan-Yu Ma, Jing-Jing Zhu, Jian-Guo Jiang, Li Liu, Yan-Kui Yi, Hong-Xia Zhu, Qiang LiuIndustrial crops and products 157, pp.112893 (2020)[Overseas Papers] Medicinal Value and Potential Therapeutic Mechanisms of Gynostemma pentaphyllum (Thunb.) Makino and Its Derivatives: An OverviewLi, Kaijun, Ma, Chao, Li, Haoyu, Dev, Sooranna, He, JianFeng, Qu, XiaoshengCurrent topics in medicinal chemistry 19(31), pp.2855 - 2867 (2020)[International Paper] Protective effects of dammarane-type triterpenes from hydrolyzate of Gynostemma pentaphyllum against H2O2-induced injury and anti-hepatic fibrosis activitiesZhang, Xiaoshu, Shi, Guohui, Liu, Mingbing, Chen, Rong, Wu, Xiaojun, Zhao, YuqingPhytochemistry letters 25, pp.33 - 36 (2018)[Overseas Papers] Isolation, Structures, and Bioactivities of the Polysaccharides from Gynostemma pentaphyllum (Thunb.) Makino: A ReviewJi, Xiaolong, Shen, Yingbin, Guo, XudanBioMed research international 2018, pp.6285134 (2018)[Overseas Papers] Bioassay-guided isolation and identification of anticancer and antioxidant compounds from Gynostemma pentaphyllum (Thunb.) MakinoWang, Tian-Xing, Shi, Man-Man, Jiang, Jian-GuoRSC advances 8(41), pp.23181 - 23190 (2018)[International Paper] The inhibitory effect of gypenoside stereoisomers, gypenoside L and gypenoside LI, isolated from Gynostemma pentaphyllum on the growth of human lung cancer A549 cellsXing, Shao-Fang, Liu, Lin-Hua, Zu, Ma-Li, Ding, Xiao-Fan, Cui, Wei-Ye, Chang, Tuo, Piao, Xiang-LanJournal of ethnopharmacology 219, pp.161 - 172 (2018)[Overseas Papers] Characteristics, composition, and antioxidant activities in vitro and in vivo of Gynostemma pentaphyllum (Thunb.) Makino seed oilWang, Lu, Pang, Min, Wang, Xiaobing, Wang, Pan, Xiao, Yaping, Liu, QuanhongJournal of the science of food and agriculture 97(7), pp.2084 - 2093 (2017)[Overseas Paper] In Vitro Anticancer Activity of a Nonpolar Fraction from Gynostemma pentaphyllum (Thunb.) MakinoLi, Yantao, Huang, Jiajun, Lin, Wanjun, Yuan, Zhongwen, Feng, Senling, Xie, Ying, Ma, WenzheEvidence-based Complementary and Alternative Medicine 2016, pp.6308649 (2016)[International Paper] Anti-cancer effects of Gynostemma pentaphyllum (Thunb.) Makino ( Jiaogulan )Li, Yantao, Lin, Wanjun, Huang, Jiajun, Xie, Ying, Ma, Wenzhe[International Paper] Chemical composition and anti-proliferative and anti-inflammatory effects of the leaf and whole-plant samples of diploid and tetraploid Gynostemma pentaphyllum (Thunb.) MakinoXie, Z., Huang, H., Zhao, Y., Shi, H., Wang, S., Wang, TTY, Chen, P., Yu, LFood chemistry 132(1), pp.125 - 133 (2012)[Overseas Paper] Gynostemma pentaphyllum Decreases Allergic Reactions in a Murine Asthmatic ModelHuang, Wen-Chung, Kuo, Ming-Ling, Li, Ming-Liang, Yang, Rong-Chi, Liou, Chian-Jiun, Shen, Jiann-JongThe American journal of Chinese medicine 36(3), pp.579 - 592 (2008)[Overseas Papers] Cholesterol-lowering effects of Gynostemma pentaphyllum (Thunb) MakinoKy, PT, Canh, VE, Huong, PT, Phuong, NKDuoc hoc 5, pp.9 - 10 (2007)[Korea Patent] Composition For Anti-inflammation and Prevention of Hair loss Comprising the Indicator Ingredient isolated from the Extract of Gynostemma PentaphyllumKorea |Register |Applicant : Celltrion Co., Ltd.;|Application No.: 10-2020-0023931 (2020-02-26) |Registration number: 10-2189376-0000 (2020-12-04)[Korea Patent] An anti-inflammatory composition comprising an Gynostemma pentaphyllum distillate and hydrogen as an active ingredientKorea |Register |Applicant : Cheonjiae Cooperative;|Application No.: 10-2018-0125091 (2018-10-19) |Publication number: 10-2020-0044391 (2020-04-29) |Registration number: 10-2183311-0000 (2020-11-20)[Korean Patent] Method for producing ginsenoside from adventitious root of Gynostemma pentaphyllumKorea |Register |Applicants: Center for Intelligent Biosystems Design and Synthesis Research Foundation;|Application No.: 10-2018-0084749 (2018-07-20) |Publication No.: 10-2019-0010487 (2019-01-30) |Registration number: 10-2096348-0000 (2020-03-27)[Korea Patent] A Composition for Increasing Muscle Mass and Preventing Muscle Loss Using Gynostemma Pentaphyllum Leaves ExtractKorea |Register |Applicant: BTC Co., Ltd.;|Application No.: 10-2019-0035772 (2019-03-28) |Publication No.: 10-2019-0038505 (2019-04-08) |Registration number: 10-2064387-0000 (2020-01-03)[Korean Patent] Preparation Method of Gynostemma Pentaphyllum leaves Extract for Increasing small molecular effective Saponin contents, and Decreasing Benzopyrene, And Gynostemma Pentaphyllum Extract Using Thereof)Korea |Register |Applicant: BTC Co., Ltd.;|Application No.: 10-2018-0085640 (2018-07-23) |Publication No.: 10-2019-0010506 (2019-01-30) |Registration number: 10-1969062-0000 (2019-04-09)[Korea Patent] Novel Gypenoside compound isolated from Dol et al. (NOVEL GYPENOSIDE COMPOUND ISOLATED FROM GYNOSTEMMA PENTAPHYLLUM)Korea |Register |Applicant : Celltrion Co., Ltd.;|Application No.: 10-2014-0097045 (2014-07-30) |Publication No.: 10-2014-0108621 (2014-09-12) |Registration number: 10-1928767-0000 (2018-12-07)[Korean Patent] Cosmetic composition containing gynostemma pentaphyllum leaf extractKorea |Register |Applicant : Kim Se-in;|Application No.: 10-2016-0046020 (2016-04-15) |Publication No.: 10-2017-0118359 (2017-10-25) |Registration number: 10-1881954-0000 (2018-07-19)[Korea Patent] Composition for reducing hangover containing gynostemma pentaphyllum leaf extractKorea |Register |Applicant : Lee, Chang-Hyeon;|Application No.: 10-2016-0045788 (2016-04-14) |Publication number: 10-2017-0117838 (2017-10-24) |Registration number: 10-1873292-0000 (2018-06-26)[Korean Patent] Manufacturing method of Dolwoe fermented extracts comprising saponins as an active functional food ingredient and preparation method thereofKorea |Register |Applicant: National Food Cluster Support Center;|Application No.: 10-2015-0190943 (2015-12-31) |Publication No.: 10-2017-0079903 (2017-07-10) |Registration number: 10-1773081-0000 (2017-08-24)[Korea Patent] Cosmetic composition comprising gypenoside isolated from gynostemma pentaphyllum for reducing wrinkleKorea |Register |Applicant : Celltrion Co., Ltd.;|Application No.: 10-2015-0082625 (2015-06-11) |Registration number: 10-1642660-0000 (2016-07-19)[Korean Patent] Gynostemma pentaphyllum preventing extracts for treating or preventing inflammatory diseases comprising the extract as an active ingredient (Gynostemma pentaphyllum)Korea |Register |Applicant : Shindo Industrial Co., Ltd.;|Application No.: 10-2012-0010903 (2012-02-02) |Publication number: 10-2012-0086278 (2012-08-02) |Registration number: 10-1352972-0000 (2014-01-13)[Korean Patent] Manufacturing method of extract of dolesaceae using supercritical carbon dioxide and cosmetic composition for preventing skin aging containing same (Gynostemma pentaphyllum extract with anti-aging activity and process for preparing the same using supercritical carbon dioxide extraction)Korea |Register |Applicant: Cosmax Co., Ltd.;|Application No.: 10-2006-0079905 (2006-08-23) |Publication No. : 10-2008-0017963 (2008-02-27) |Registration number: 10-1337213-0000 (2013-11-29)[Korea Patent] Whitening cosmetic compositions comprising crude saponins of Gynostemma pentaphyllumKorea |Register |Applicant: Cosmax Co., Ltd.;|Application No.: 10-2006-0085348 (2006-09-05) |Publication No.: 10-2008-0022010 (2008-03-10) |Registration number: 10-1328394-0000 (2013-11-06)[Korea Patent] The pharmaceutical agents for the ameliorating effect on stress from the extracts of Gynostemma pentaphyllumKorea |Register |Applicant: Chungbuk National University Industry-University Cooperation Foundation;|Application No.: 10-2008-0127748 (2008-12-16) |Publication No.: 10-2010-0069142 (2010-06-24) |Registration number: 10-1047755-0000 (2011-07-01)[US Patent] Melanogenesis effect of saponins of gynostemma pentaphyllumUnited States (US) |Register |Applicant: Hong Kong Baptist University;|Application No. : US-0165560 (2014-01-27) |Patent No.: US-9539275 (2017-01-10) |Registration number: US-9539275 (2017-01-10)[US Patent] GYNOSTEMMA PENTAPHYLLUM-CONTAINING HEALTH CARE PHARMACEUTICAL COMPOSITION FOR PREVENTING HYPERLIPIDEMIA, HYPERTENSION, HYPERGLYCEMIA AND GOUTUnited States (US) |public |Applicant: WANG;Shaoke;|Application No.: US-0184286 (2018-11-08) |Publication number: US-0070240 (2019-03-07)[International Patent]COMPOSITION COMPRISING GYPENOSIDE EXTRACT OF GYNOSTEMMA PENTAPHYLLUM (THUNB.) MAKINO FOR TREATING OR PREVENTING TYPE IotaIota DIABETES, OBESITY, OR HYPERLIPIDEMIAInternational (WO) |public |Applicant: CELLTRION INC;|Application No. : KR-0010722 (2012-12-11) |Publication No.: WO-0089402 (2013-06-20)[International Patent]DIETARY SUPPLEMENT FOR PROMOTING CONTROL OF BLOOD-SUGAR LEVELS AND ASSOCIATED PATHOLOGY IN TYPE 2 DIABETICSInternational (WO) |public |Applicant: SANTÉ |Application No. : US-0022330 (2004-07-13) |Patent number: WO-5009351 (2005-04-28)[International Patent]DIETARY SUPPLEMENT FOR PROMOTING CONTROL OF BLOOD-SUGAR LEVELS AND ASSOCIATED PATHOLOGY IN TYPE 2 DIABETICSInternational (WO) |public |Applicant: SANTÉ |Application No. : US-0022330 (2004-07-13) |Patent number: WO-5009351 (2005-02-03)[Japanese Patent] SUPPLEMENT CONTAINING SENNA TEA AND GYNOSTEMMA PENTAPHYLLUM (THUNB.) MAKINO OR EXTRACT OF THEMJapan (JA) |public |Applicant: RASHERU SEIYAKU KK;|Application No.: JP-0119809 (2004-04-15) |Patent number: JP-0295943 (2005-10-27)[Japanese Patent] CELL ACTIVATING FOOD SUCH AS HAIR GROWTHJapan (JA) |public |Applicant: NANBAA THREE:KK;SHIBA TRADING KK;|Application No.: JP-0109167 (1984-05-29) |Patent number: JP-0251866 (1985-12-12)Antidiabetic Effects of Add-On Gynostemma pentaphyllum Extract Therapy with Sulfonylureas in Type 2 Diabetic PatientsVTT Huyen, DV Phan, P. Thang, PT Ky, NK Hoa, and CG OstensonEvidence-Based Complementary and Alternative Medicine 2012, pp.1-7 (2012)Anticancer and immunoregulatory activity of Gynostemma pentaphyllum polysaccharides in H22 tumor-bearing mice.Liu J, Zhang L, Ren Y, Gao Y, Kang L and Qiao QInt J Biol Macromol 69, pp.1-4 (2014)Antimicrobial activity of Gynostemma pentaphyllum extracts against fungi producing aflatoxin and fumonisin and bacteria causing diarrheal disease.Srichana, D., Taengtip, R. and Kondo, S.Southeast Asian J. Trop.Med.Public Health 42, pp.704-710 (2011)The anti-gastric ulcer effect of Gynostemma pentaphyllum Makino.Rujjanawate, C., Kanjanapothi, D., and Amornlerdpison, D.Constituents of collagen synthesis activation from the extracts of Gynostemma pentaphyllum leaves.Yim JH, Jang MS, Jung US, Moon MY, Lee HY, Kim YH, Lee GY, Lee NH.Journal of the Society of Cosmetic Scientists of Korea 43, pp.289-295 (2014)Gypenosides altered hepatic bile acids homeostasis in mice treated with high fat diet.Lu Y, Du Y, Qin L, Wu D, Wang W, Ling L, Ma F, Ling H, Yang L, Wang C, Wang Z, Zhou X and He YEvid Based Complement Alternat Med 2018(3), pp.1-10 (2018)Antioxidative and cellular protective effects of Dolwoe (Gynostemma pentaphyllum Makino) extracts against oxidative stress.Kim KM, Kim AR, Kim AY, Ha JH, Xuan SH, Jeong YJ, Park YM, Jeong HJ, Hong IG, Park SN.Korean Journal of Pharmacognosy 48, pp.125-133 (2017)